Views: 5 Author: Grand packing machinery Publish Time: 2025-02-05 Origin: Grandpacking.com
For the materials with poor compressibility, adding some diluent can increase its volume, reduce the friction between particles, and make the material easier to flow and deform under pressure. For example, lactose is a commonly used diluent that has good flowability and compressibility. For medicines with poor compressibility, after adding an appropriate amount of lactose, the lactose particles can be filled between the medicine particles to make the overall material fluidity better. During the tablet pressing process, the lactose particles are deformed under pressure, which helps to bind the medicine particles together, thus improving the tablet pressing performance.
The preparation of traditional medicine tablets need use many medicine extracts with poor compressibility. We can add starch and other diluent, to reduce the looseness of the medicines, making it be easier to form hard tablets when compressing.
The adhesive can increase the adhesion of material particles. For materials with poor compressibility, the binding between particles is weak, and it is difficult to form a stable tablet structure under pressure. For example, HPMC is used as a binder, which forms an adhesive film on the surface of the particles. When pressure is applied, this adhesive film causes the particles to adhere to each other to form a tablet. Adhesives can also improve the material plasticity, making the particles be easier to deform and bond into a tablet under pressure.
In the preparation of vitamin C tablets, due to the poor compressibility of vitamin C crystals, we can add polyvinylpyrrolidone (PVP) as an adhesives to improve the bonding, hardness and integrity of the tablets.
The lubricant is mainly to reduce the friction between the particles and the punching die, and that among the particles. For materials with poor compressibility, due to the large friction among the particles, it may lead to uneven surface and cracking of the tablet during the tablet pressing process. Magnesium stearate is a common lubricant that forms a lubricating film on the surface of particles, which reduces friction so the particles can move and bond more smoothly in the mold.
At the same time, it also reduces the wearing of punching die and prolongs its service life.
When compressing compound tablets containing difficult-to-press materials, such as amino acid components, adding magnesium stearate can effectively improve the fluidity and demolding, making the tablet easier to push out of the forming mold with a smoother surface.
Through granulation, small particles can be aggregated into larger particles to reduce the proportion of fine powder. For materials with poor compressibility, the fine powder is too much, its specific surface area and the cohesion and friction between particles are large, so the compressibility is poor. For example, for wet granulation, pharmaceutical powders are mixed with adhesives to make granules. During this process, the powder is bonded together by the adhesives, the particles become larger with better fluidity.
At the same time, the deformation of the particles under pressure is also changed to easier form a tight tablet structure.
In the preparation of antibiotic tablets, many antibiotic medicine powders have poor compressibility. Through wet granulation, the compressibility is significantly improved, and it can be smoothly pressed into tablets of good quality.
For materials in crystalline form, it is more conducive to press tablets by changing the crystallization conditions. For example, acicular crystallized materials are often low compressible and flowable. By controlling the crystallization temperature, stirring speed and other factors to make it crystallize into a spherical or spherical shape, so the crystalline particles have better fluidity and compressibility. Since there is less friction among spherical particles, the deformation under pressure is more conducive to tight bonding.
In the production of some alkaloid medicines, via optimizing crystallization process, the original needle-like crystallization is transformed into spherical crystals, and the filling performance and compressibility of the material have been significantly improved during tablet pressing, reducing splinters and cracking.
Some medicines with multiple cyrstal forms, and their compressibilities are different. For example, medicine with metastable crystalline forms typically have higher energy and better compressibility. Tableting performance can be improved by converting a medicine into a more tablet-friendly crystalline form with appropriate methods, such as heating, solvent-mediated, etc.
In the preparation of some steroid medicines, by controlling the crystallization solvent and temperature, the medicine is transformed from one crystal form to another that is easier to compress, then the medicine can form a tablet with good hardness at a lower pressure during the tableting process.
For poorly soluble medicines, making them into solid dispersion can improve their compressibility and dissolution properties. A solid dispersion is that the medicine in a molecular, amorphous, or microcrystalline state to disperse in another water-soluble material. For example, a solid dispersion of poorly soluble medicine is made by using polyethylene glycol (PEG) as a carrier. During this process, the medicine physical state changes, and the particles become smaller, so the specific surface area increases, and there is an interaction between the medicine and the carrier.
When tablet press, the solid dispersion is generally more compressible than the original because the carrier material can improve fluidity and inter-particle adhesion.
Ibuprofen is a poorly soluble medicine. During preparation of ibuprofen tablets, after it is made into a solid dispersion with polyvinylpyrrolidone (PVP) as the carrier, the compressibility and dissolution have been significantly improved, so the medicine increases the therapeutic effect better.
Welcome to Our Website
English
